Beyond Hormones: Researchers Define X and Y Chromosome Contributions to Height
- On May 19, 2025, researchers published a study in PNAS analyzing nearly one million US and UK genomes to explore height differences.
- They studied rare cases of individuals with extra or missing X or Y chromosomes to understand genetic contributions to height.
- The study revealed that possessing an additional Y chromosome results in a greater increase in height than having an extra X chromosome, independent of sex hormone effects.
- Senior author Matthew Oetjens noted that this genetic factor accounts for roughly 20 percent of the typical height gap observed between males and females, indicating a modest but meaningful contribution.
- These findings suggest that the SHOX gene on sex chromosomes partly drives male-female height differences, with hormones likely accounting for the rest.
42 Articles
42 Articles
Y chromosome found to play key role in making men taller than women
Height is one of the most evident sex-based differences observed in humans, as men are on an average 13 cm (5 inches) taller than women. Sex hormones certainly play a significant role in driving this dimorphism, but they are not the only factors at play.
'Definitely Cool' Study Digs Into Male-Female Height Gap
Why are men, on average, taller than women? A massive new genetic study reveals how a single gene may account for a slice of the difference. The SHOX gene has been thought to influence height—but since it's present on both X and Y chromosomes, researchers could only hypothesize that...

Scientists Find Gene That Helps Explain Why Men Are Taller Than Women
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