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New WHO Guidelines Recommend Injectable Lenacapavir for HIV Prevention

KIGALI, RWANDA, JUL 14 – WHO urges immediate global use of twice-yearly injectable lenacapavir to address 1.3 million new HIV infections in 2024 and improve prevention among high-risk groups.

  • On July 14, 2025, at the IAS 2025 conference in Kigali, WHO issued new guidelines recommending injectable lenacapavir twice yearly for HIV prevention.
  • This guidance responds to 1.3 million new HIV infections reported in 2024 amid declining global funding threatening HIV prevention and treatment efforts.
  • Lenacapavir, a long-acting antiretroviral, has demonstrated in clinical trials the ability to nearly eliminate new HIV infections, providing an important alternative to daily pill regimens that are often hindered by stigma and limited access.
  • WHO Director-General Tedros Ghebreyesus called LEN "the next best thing," urging immediate rollout alongside simpler rapid HIV testing to increase accessibility.
  • These guidelines could reshape the global HIV response, though experts stress bold, equitable implementation amid ongoing financial and systemic challenges worldwide.
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UN News broke the news in New York, United States on Monday, July 14, 2025.
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