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What to know about melatonin supplements and heart health risks

This past week, the American Heart Association announced a preliminary research abstract linking long-term melatonin use in adults with insomnia to higher heart failure diagnoses and hospitalizations.
Using prescription fills as the marker, researchers compared five years of electronic health records for adults with insomnia who had long-term melatonin use, noting prescription evidence may misclassify over-the-counter users.
Analysis showed melatonin users faced nearly 3.5 times the heart-failure hospitalizations, with hospitalization rates of 19.0% versus 6.6% for nonusers.
Given the study's observational design, Ekenedilichukwu Nnadi, M.D., said if confirmed it could affect how doctors counsel patients, while the American Heart Association and experts urged more research.
Contradicting prior research suggesting benefits, the study will be presented at the American Heart Association Scientific Sessions 2025, and heart failure affects 6.7 million adults in the U.S., noted media including The Washington Post.

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Does melatonin increase heart failure risk? New study reveals surprising link

If you often find yourself reaching for melatonin gummies to help you sleep, you may want to take a step back. New research suggests that chronic use of melatonin supplements could be a warning sign of heart failure among people with insomnia. The research, which is scheduled to be presented at a meeting of the American Heart Association and has not been peer reviewed, relied on electronic health record data. For the study, researchers looked at…

20 hours ago·Fort Worth, United States

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