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What to know about melatonin supplements and heart health risks

  • This past week, the American Heart Association announced a preliminary research abstract linking long-term melatonin use in adults with insomnia to higher heart failure diagnoses and hospitalizations.
  • Using prescription fills as the marker, researchers compared five years of electronic health records for adults with insomnia who had long-term melatonin use, noting prescription evidence may misclassify over-the-counter users.
  • Analysis showed melatonin users faced nearly 3.5 times the heart-failure hospitalizations, with hospitalization rates of 19.0% versus 6.6% for nonusers.
  • Given the study's observational design, Ekenedilichukwu Nnadi, M.D., said if confirmed it could affect how doctors counsel patients, while the American Heart Association and experts urged more research.
  • Contradicting prior research suggesting benefits, the study will be presented at the American Heart Association Scientific Sessions 2025, and heart failure affects 6.7 million adults in the U.S., noted media including The Washington Post.
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What to know about melatonin supplements and heart health risks

Melatonin supplements have been linked with heart failure in new research. Here’s what you should know.

·Atlanta, United States
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Taking prolonged melatonin supplements to fight insomnia may not be harmless. According to a new study, ...

·Chile
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redaccionmedica.com broke the news in on Tuesday, November 4, 2025.
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