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Gliocidin Is a Nicotinamide-Mimetic Prodrug That Targets Glioblastoma

Summary by Science News
Scientists identified a small compound, gliocidin, that killed glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targeted a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2. [Nature] Abstract
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