Epigenetic therapy in immune-oncology

Epigenetic therapy in immune-oncology

DNA methylation inhibitors have become the mainstay for treatment of certain haematological malignancies. In addition to their abilities to reactivate genes, including tumour suppressors, that have acquired DNA methylation during carcinogenesis, they induce the expression of thousands of transposable elements including endogenous retroviruses and latent cancer testis antigens normally silenced by DNA methylation in most somatic cells. This resul…

Heterochromatin's Transposable Elements Kept in Check by OGT Enzyme

Heterochromatin, sometimes known as the “dark side of the genome,” is a poorly studied fraction of DNA that makes up about half of our genetic material. For more than 50 years scientists have puzzled over the genetic material contained in this “dark DNA,” but are now starting to unravel its role in cells. There’s a growing body of evidence showing that its proper functioning is critical for maintaining cells in a healthy state. Heterochromatin c…

Epigenetic marks are chemical changes in DNA that will enable the activation or suppression of certain genes. They are reproduced when the cells divide but can they

Epigenetic brands are chemical modifications of DNA that will enable the activation or suppression of certain genes. They are reproduced when the cells are divided but can they be separated between two generations? Bantignies Frédéric, University of Montpellier and Giacomo Cavalli, University of Montpellier At the basis of genetic information, DNA is the founding molecule of the...