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Sanofi’s Neuro Pipeline Expands to Alzheimer’s With $470M Vigil Neuroscience Acquisition

  • Sanofi has agreed to acquire the US-based clinical-stage company Vigil Neuroscience for $470 million in cash to strengthen its neurology portfolio with a potential new treatment for Alzheimer's disease.
  • Last year, Sanofi invested $40 million in Vigil, securing rights to VG-3927, an oral TREM2-targeting drug currently undergoing Phase 1 trials.
  • VG-3927 safely stimulates TREM2 receptors on brain microglia, which are linked to neurodegeneration, and Vigil plans a Phase 2 trial in Q3 2025.
  • The offer price of $8 per share represents a 246% premium over Vigil’s recent stock price, with an additional $2 per share contingent on VG-3927’s commercial launch.
  • The acquisition expands Sanofi’s neurology focus, transferring VG-101 rights back to Amgen, and may provide a new treatment approach amid limited Alzheimer’s options.
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MobiHealthNews broke the news in on Wednesday, May 21, 2025.
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