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Vitamin D in Tailored Doses Found to Reduce Heart Attack Risk

TARGET-D trial shows tailored vitamin D doses reduced heart attack risk by 52% in 630 heart disease patients, with doses often exceeding 5,000 IU daily, researchers said.

  • At the American Heart Association annual meeting in New Orleans, investigators reported personalized vitamin D dosing cut heart attack risk by 52% in the TARGET-D randomized trial.
  • Previous uniform-dose vitamin D trials tested the same dose for all participants, but this study measured participant vitamin D blood levels with more than 85% of participants starting below 40 ng/mL.
  • The randomized trial enrolled 630 adults with heart disease at Intermountain Medical Center, averaging around 63 years old with 107 major heart health problems recorded.
  • However, investigators found the vitamin D intervention did not lower death, heart failure or stroke risk, with benefits restricted to heart attack; Heidi May urged more clinical trials and clinician discussions.
  • Because results were presented at meetings, experts urge that about half the vitamin D group required more than 5,000 IU daily, exceeding the U.S. Food and Drug Administration 800 IU daily recommendation.
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Tailored Doses of Vitamin D Halve Heart Attack Risk

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  • 43% of the sources are Center, 43% of the sources lean Right
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MedPage Today broke the news in New York, United States on Tuesday, November 11, 2025.
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