CAR-T Therapy Dilemma and Innovative Design Strategies for Next Generation

CAR-T therapy dilemma and innovative design strategies for next generation

Chimeric antigen receptor (CAR)-T-cell therapy has shown remarkable curative effects on hematological tumors, driving the exponential growth in CAR-T-related research. Although CD19-targeting CAR-T-cell therapy has displayed remarkable promise in clinical trials, many obstacles are arising that limit its therapeutic efficacy in tumor immunotherapy. The “dilemma” of CAR-T cell-based tumor therapy includes lethal cytotoxicity, restricted trafficki…

Engineered cell cross-talk unlocks CAR-T potential against glioblastoma

A team of researchers from the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan), led by Nadia Coltella and Luigi Naldini, has unveiled a powerful strategy to rejuvenate the effectiveness of chimeric antigen receptor (CAR) T cell therapy against glioblastoma, one of the most lethal and treatment-resistant brain tumors.

Engineered Cellular Communication Enhances CAR-T Therapy Effectiveness

A groundbreaking advancement in the fight against glioblastoma, one of the deadliest and most treatment-resistant brain tumors, has emerged from researchers at the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET) in Milan. This multidisciplinary team, led by Nadia Coltella and Luigi Naldini, has devised an innovative gene therapy strategy designed to restore and enhance the […]

Veteran Credits CAR T-Cell Therapy With Helping Him Reach Remission

Mark Daniels, 83, says CAR T-cell therapy and strong support helped him overcome lymphoma twice and return to the fitness-focused life he values.