Vascularized stem cell islet organoids offer improved model for diabetes research

Vascularized stem cell islet organoids offer improved model for diabetes research

Researchers led by Maike Sander, scientific director of the Max Delbrück Center, have developed a vascularized organoid model of hormone-secreting cells in the pancreas. The advance, published in Developmental Cell, promises to improve diabetes research and cell-based therapies.

New Stem Cell Islet Model Mimics Pancreatic Function More Accurately

Researchers led by Maike Sander, Scientific Director of the Max Delbrück Center, have developed a vascularized organoid model of hormone secreting cells in the pancreas.

First Vascularized Organoid Model of Stem Cell-Derived Pancreatic Islets

An international team of researchers led by Max Delbrück Center Scientific Director Professor Maike Sander, MD, has for the first time developed an organoid model of human pluripotent stem cell-derived pancreatic islets (SC-islets) with integrated vasculature. Researchers in the Sander lab at the University of California, San Diego, found that SC-islet organoids with blood vessels contained greater numbers of mature β cells and secreted more ins…