Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex

Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex

As a chronically replicating virus, HIV has evolved extreme sequence variability and effective shielding of functionally constrained spike protein determinants by host-derived glycans1. Broadly neutralizing antibodies, although rare, can be isolated from people living with HIV, revealing conserved envelope glycoprotein (Env) sites as key targets for vaccine development2–4. One such target is the apex of the Env spike. Here we identify a vaccinat…