US EditionUnveiling IDH-mutant glioma's roots: A new path for early diagnosis
Researchers found glial progenitor cells acquire IDH mutations long before tumors form, enabling new early diagnosis and treatment strategies targeting tumor origins.
5 Articles
5 Articles
Origin cells for common malignant brain tumor in young adults uncovered
IDH-mutant glioma, caused by abnormalities in a specific gene (IDH), is the most common malignant brain tumor among young adults under the age of 50. It is a refractory brain cancer that is difficult to treat due to its high recurrence rate.
Origins of Brain Cancer: Where IDH-Mutant Gliomas Begin
IDH-mutant glioma is the most common malignant brain tumor in adults under 50, yet it remains one of the most difficult to treat. Even after extensive surgery and therapy, recurrence is common. A new study from the Korea Advanced Institute of Science and Technology (KAIST) and Yonsei University Severance Hospital, published in Science, suggests a fundamental reason why: the cancer may already be widespread in the brain long before it can be seen…
For the first time, the origin and origin of intractable brain cancer caused by mutations in the IDH gene have been revealed. This is expected to lead to a paradigm shift in early diagnosis and treatment of brain tumors to prevent recurrence. The research results were published in the international journal Science.
IDH-Mutant Gliomas Arise from Glial Progenitor Cells Harboring the Initial Driver Mutation
Scientists conducted deep sequencing on 142 tissues from 70 individuals with isocitrate dehydrogenase (IDH)–mutant gliomas comprising tumors, peritumoral cortex or subventricular zones, and blood. [Science] AbstractGraphical Abstract
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