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After Off-Grid Trip, Nobel Medicine Laureate Fred Ramsdel Connects With Committee and Shares Reaction

  • On Monday, the Nobel Assembly in Stockholm named Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi as recipients of the 2025 Nobel Prize in Medicine for their work on how the immune system regulates itself.
  • The committee recognized their work, which built on Sakaguchi’s 1995 discovery of regulatory T cells and Brunkow and Ramsdell’s 2001 finding of a crucial gene tied to autoimmune disease.
  • Their discoveries identified regulatory T-cells as the immune system's 'security guards' and have opened a new field leading to possible treatments for cancer and autoimmune conditions.
  • The award, worth 11 million Swedish krona, was difficult to deliver as the committee could not reach Ramsdell, reportedly on an 'off the grid' hiking trip, with the secretary general stating, 'I asked them to, if they have a chance, call me back.'
  • The committee expressed optimism that this research will lead to new treatments for autoimmune disorders and improve cancer therapies.
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Fred Ramsdell was hiking in Montana without cell phone coverage. When his wife suddenly screamed out loud, he thought she had seen a grizzly bear. – You just won N

·Stockholm, Sweden
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Fred Ramsdell was on a three-week hike in the Rocky Mountains with his wife and they couldn't reach her. His wife finally broke the news to him when they got to a place with signal.

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France24 broke the news in France on Monday, October 6, 2025.
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