Decoding the Mechanisms of Chimeric Antigen Receptor (CAR) T Cell-Mediated Killing of Tumors: Insights From Granzyme and Fas Inhibition

Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition

Chimeric antigen receptor (CAR) T cell show promise in cancer treatments, but their mechanism of action is not well understood. Decoding the mechanisms used by individual T cells can help improve the efficacy of T cells while also identifying mechanisms of T cell failure leading to tumor escape. Here, we used a suite of assays including dynamic single-cell imaging of cell-cell interactions, dynamic imaging of fluorescent reporters to directly tr…

Unlocking the promise of CAR-T — Harvard Gazette

Health Unlocking the promise of CAR-T Alvin Powell Harvard Staff Writer June 30, 2025 long read Research across multiple fronts seeks to expand impact of a cancer therapy that has left patients and doctors awestruck David Avigan doesn’t like to use the word “miracle” to describe CAR-T-cell therapy, but he knows what people mean when they do. He also remembers the first time it happened with one of …