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Universal vaccine for cold, flu, COVID and allergies 'moves a step closer'
The nasal vaccine provided several months of lung protection in mice against viruses, bacteria, and allergens, and human trials are planned to confirm efficacy.
- Researchers at Stanford Medicine published findings today showing a nasal‑spray vaccine, GLA-3M-052-LS+OVA, protected mice against diverse respiratory viruses, bacteria and allergens for at least three months.
- By design, the vaccine mimics T‑cell signals to stimulate the innate immune system and recruit T cells in the lungs, a radical departure from conventional vaccines used for more than 200 years.
- In lab tests, mice given four doses experienced a 100-to-1,000-fold reduction in viral entry and protection against Staphylococcus aureus, Acinetobacter baumannii, and house dust mites.
- The team plans human trials that would start with a safety trial followed by a deliberate-exposure trial, estimating availability in five to seven years if funded, though effects in people remain unknown.
- Experts hailed the work as promising yet cautioned that if translated to humans, the vaccine could replace multiple annual respiratory shots and offer a pandemic first‑line defence, though immune overactivation risks remain.
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35 Articles
Stanford's New "Universal Vaccine Formula" Nasal Spray Protects Mice Against Stunning Range of Diseases
Stanford Medicine researchers claim they’ve invented a “universal vaccine formula” that protects mice against a wide range of allergens, bacteria, and respiratory viruses. And instead of being administered by injection, the potential cure-all can be taken as a simple nasal spray. If the formula, detailed in a recent study published in Science, could be applied to humans, it would be game-changer for people vulnerable to seasonal respiratory in…
American researchers are developing a universal vaccine that could protect not only against influenza or Covid, but also against almost all respiratory viruses and several bacteria.
A nasal spray that fights all viruses, bacteria, and even allergies
For more than 200 years, vaccines have worked the same way: teach your immune system to recognize a specific invader, then wait. Stanford researchers are trying something fundamentally different — a nasal spray that skips the teaching and just puts your lungs on permanent high alert. — Read the rest The post A nasal spray that fights all viruses, bacteria, and even allergies appeared first on Boing Boing.
Researchers develop nasal vaccine offering wide protection against viruses and bacteria in mice
Stanford Medicine researchers have developed a novel nasal vaccine that provides mice with broad protection against respiratory viruses, bacteria, and allergens. This innovative approach mimics immune cell communication signals, integrating innate and adaptive immunity for sustained, wide-ranging defense. The vaccine offers a promising step towards a universal respiratory vaccine, potentially simplifying annual immunizations and preparing for fu…
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