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Understanding ‘Off’ Times in Advanced Parkinson’s Disease

Parkinson’s disease , a progressive nervous system movement disorder, weakens and damages nerve cells in parts of the brain. This leads to declining production of brain chemicals, says Karen M. Thomas, DO , a neurologist and the director of the Comprehensive Parkinson's Disease & Movement Disorders Program at Sentara Health in Virginia Beach, Virginia. “The most significant chemical affected is dopamine , which is used by the nervous system and …

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EverydayHealth.com broke the news in on Thursday, January 8, 2026.
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