DNA repair protein's unexpected structure may lead to new cancer treatments

Newfound Role for Cancer Gene Could Improve Key Drug Class

NEW YORK, April 3, 2025 /PRNewswire/ -- A study led by NYU Langone Health researchers sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP…

New structural and mechanistic understanding for cancer drug design

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and mechanistic understanding of the RAD52-DNA complex may help researchers develop new anti-cancer drugs.

DNA repair protein's unexpected structure may lead to new cancer treatments

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and mechanistic understanding of the RAD52-DNA complex may help researchers develop new anti-cancer drugs.

UAMS Awarded Nearly $3M to Study DNA Cancer Treatment

UAMS researcher Kevin Raney has been awarded a five-year, $2.99 million grant from the National Institutes of Health (NIH) to study unusual DNA structures called quadruplexes, which could act like natural drugs for diseases like cancer. The grant from the NIH National Institute of General Medical Sciences aims to help Raney fully understand the role of quadruplexes and their potential for targeted therapies. “I think that taking advantage of the…

In particular, it demonstrates the involvement of Ubp1 protein in the mechanisms of duplication of the genome. The data obtained contribute to a better understanding of the molecular mechanisms that allow cells to protect the integrity of the genome during replication, when DNA is more susceptible to modifications that can contribute to the genesis of diseases such as cancer. The research recently published in the journal Nucleic Acids Research …