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Top science stories of 2025

The first personalized CRISPR gene therapy was administered to a baby in 2025, and FDA approved initial pig organ transplant trials, marking milestones in gene editing and xenotransplantation.

  • This year, a baby boy became the first patient to receive a personalized CRISPR therapy, while the Center for Pediatric CRISPR Cures in California launched, funded by the Chan Zuckerberg Initiative and led by UC Berkeley and UC San Francisco.
  • A surge in gene‑therapy results helped pave the way as Amsterdam-based uniQure infused 29 Huntington's disease patients with microRNAs, slowing progression by 75% at higher doses.
  • Regulators and surgeons advanced pig‑organ transplants as the Food and Drug Administration green‑lit multiperson pig kidney trials; experimental pig lung and kidney transplants included one lasting nearly nine months, while an enzyme for blood‑type conversion showed promise.
  • Surgeons expect transplant volume to rise from current handfuls, with Joseph Ladowski forecasting about 'half a dozen' more animal‑organ transplants this year and a steep increase thereafter.
  • Astronomers also scored a major win with Rubin coming online, featuring a 3.2 billion‑pixel camera and a project goal to catalog 5 million asteroids this year.
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RECIT - Never have the investments been so high for this promising technology, and some large groups are starting to equip themselves. But European start-ups in the sector will need massive financial support to keep themselves from being distanced.

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constellationr.com broke the news in on Monday, December 29, 2025.
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