Myelin–Axon Interface Vulnerability in Alzheimer’s Disease Revealed by Subcellular Proteomics and Imaging of Human and Mouse Brain

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain

Myelin ensheathment is essential for rapid axonal conduction, metabolic support and neuronal plasticity. In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. We implemented proximity labeling subcellular proteomics of the myelin–axon interface in postmortem human brains from AD donors and 15-month-old male and female 5XFAD mice. We uncovered multiple dysregulated signa…

High-resolution images reveal similarities in protein structures between Alzheimer's disease and Down syndrome

More than 90% of people with Down syndrome, the most common chromosomal disorder in humans and the most frequent genetic cause of intellectual disability, are diagnosed with Alzheimer's disease by ages 55–60.

To Understand Alzheimer’s Disease, Researchers Turn to Myelin Sheath

The disruption of axons—the thread-like part of nerve cells that transmits electrical signals—is associated with Alzheimer’s disease. One way axonal function may be hindered is through damage to the myelin sheath, a fatty coating that wraps around axons. Similar to the plastic or rubber used to insulate a cable, the my...

Rewrite Myelin–axon interface vulnerability in Alzheimer’s disease

Myelin ensheathment is essential for rapid axonal conduction, metabolic support and neuronal plasticity. In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. We implemented proximity labeling subcellular proteomics of the myelin–axon interface in postmortem human brains from AD donors and 15-month-old male and female 5XFAD mice. We uncovered multiple dysregulated signa…