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South Africa’s health minister hails new HIV prevention jab but warns of limited supply

South Africa aims to prevent new HIV infections with lenacapavir, targeting 456,000 people in two years, funded by a $29.2 million Global Fund grant.

  • On Tuesday, Health Minister Aaron Motsoaledi announced South Africa will begin rolling out the twice-yearly jab lenacapavir in April next year and warned initial donated supply will be limited to nearly half a million people.
  • Mathematical modelling suggests that if two to four million people use lenacapavir over 12 to 24 months, the South African government must buy millions of doses and create demand among HIV-negative people at high risk.
  • Clinical data show lenacapavir trials had 100% protection for women and 96% for men who have sex with men, with $29.2 million Global Fund and $5 million NACOSA funding around 456,000 initiations.
  • Motsoaledi warned demand will likely outstrip initial donated supply, urging prioritisation of vulnerable populations in high-burden districts after abrupt USAID and other U.S. government funders cuts; the U.S. announced a purchase of 2 million doses for low-income countries.
  • The minister emphasised domestic financing, with WHO recommending the jab and Gilead licensing six pharmaceutical companies to produce generics at US$40 per person per annum until 2027, and 'What revolutions are made of is reducing costs 700 times', Motsoaledi said.
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South Africa's health minister hails new HIV prevention jab but warns of limited supply

South Africa's health minister has called lenacapavir, the first twice-yearly HIV prevention jab, a "groundbreaking" tool against the disease.

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mg.co.za broke the news in on Monday, October 13, 2025.
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