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Blood Test May Predict Rapid Brain Decline in Alzheimer's Patients
- Scientists from BGI Genomics’ research institute focused on intelligent medical studies recently published findings in early June 2025 that reveal initial indicators and specific neuron types linked to the development of Alzheimer’s disease.
- The study used Smart-seq2 to analyze over 1,663 single-cell transcriptomes in the entorhinal cortex-hippocampal circuit, a key memory region affected early by Alzheimer's.
- Researchers found mitochondria fail early in disease progression, neurons produce glial-like protein GFAP, and insulin resistance worsens Alzheimer's by disrupting brain function and the blood-brain barrier.
- Dr. Bianca Gumina reported that a simple metabolic blood test, the triglyceride-glucose index, predicts which patients will face faster cognitive decline, with those in the highest third quadrupling risk.
- These findings suggest targeting metabolism could slow Alzheimer's progression, creating therapy opportunities alongside emerging disease-modifying drugs to improve early intervention strategies.
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Dementia: Neurologists identify common blood test to predict chance of developing severe Alzheimer's
A groundbreaking blood test could identify which patients with mild cognitive impairment will experience rapid progression to severe Alzheimer's disease, according to new research unveiled today
·London, United Kingdom
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Protective gene variant slows Alzheimer’s by taming brain inflammation
A rare gene mutation that delays Alzheimer's disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill Cornell Medicine.
·United States
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Daily Journal+14 Reposted by 14 other sources
Study finds blood test can predict cognitive decline in dementia patients
“We were surprised to see the effect only in the Alzheimer’s spectrum and not in other neurodegenerative diseases."
·Cherokee County, United States
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Leaning Left6Leaning Right8Center18Last UpdatedBias Distribution56% Center
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56% Center
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C 56%
R 25%
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