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Taking an Omega-3 Supplement Doesn’t Boost Memory or Cognition, Study Finds

The two-year trial found DHA levels rose 17% in the brain, but memory, cognition and hippocampal shrinkage did not improve, researchers said.

  • On Thursday, a USC study published in The Lancet eBioMedicine found high-dose Omega-3 supplements failed to improve memory or cognition in older adults, despite successfully reaching the brain.
  • The 24-month clinical trial tracked 365 adults aged 55 to 80 with dementia risk factors, testing whether daily 2,000 mg DHA doses could provide cognitive benefits associated with dietary Omega-3s.
  • While Omega-3 levels in cerebrospinal fluid rose by 17%, researchers observed no improvement in memory or hippocampal shrinkage, suggesting supplements cannot replicate benefits of a Mediterranean-style lifestyle.
  • Lead author Dr. Hussein Yassine, Volke Endowed Professor of Neurology at USC, described supplements as a "blunt instrument," while Alzheimer's researcher Dr. Richard Isaacson called the effect a "drop in the ocean."
  • Americans spend over $1 billion annually on these supplements, yet Yassine's team is now researching how dietary patterns and genetic risk influence the brain's ability to utilize nutrients for cognitive preservation.
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Taking an omega-3 supplement doesn’t boost memory or cognition, study finds

A new clinical trial found omega-3 supplements did nothing to improve memory, cognition or brain cell loss.

·Jackson, United States
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Medical Xpress broke the news on Thursday, June 18, 2026.
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