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The Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance
Their discoveries on regulatory T cells launched a new immunology field and spurred over 200 clinical trials for cancer and autoimmune disease treatments, Nobel Committee said.
- The Nobel Assembly at Karolinska Institute, Stockholm, Sweden, awarded the 2025 Nobel Prize in Physiology or Medicine jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi on Monday .
- Sakaguchi's early work in the 1990s showed he discovered regulatory T cells in 1995, while Brunkow and Ramsdell identified the Foxp3 mutation linked to autoimmune disease in 2001.
- Their papers showed that CD4+CD25+FOXP3+ regulatory T cells act as the immune system's security guards, and `The laureates’ discoveries launched the field of peripheral tolerance, spurring the development of medical treatments for cancer and autoimmune diseases` .
- Clinical researchers now run more than 200 clinical trials testing regulatory T cell therapies, and the trio will share the prize purse of 11 million Swedish kronor .
- Medicine traditionally begins Nobel week, with their work opening new possibilities for autoimmune disease and cancer research, while physics, chemistry, and literature winners follow this week.
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Elmhurst native wins Nobel Prize for work on immune systems
An immunologist born in west suburban Elmhurst is among the trio of researchers awarded the Nobel Prize in medicine Monday for their research on how the human immune system determines its targets.Fred Ramsdell, an Elmhurst native, shared the prestigious award with Dr. Shimon Sakaguchi and Mary Brunkow for their work on peripheral immune tolerance, the system that explains how the immune system knows not to attack the body’s healthy cells."Their …
The medicine Nobel Prize goes to 3 scientists for work on peripheral immune tolerance
STOCKHOLM — Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi won the Nobel Prize in medicine on Monday for their discoveries concerning peripheral immune tolerance.Brunkow, 64, is a senior program manager at the Institute for Systems Biology in Seattle. Ramsdell, 64, is a scientific adviser for Sonoma Biotherapeutics in San Francisco. Sakaguchi, 74, is a distinguished professor at the Immunology Frontier Research Center at Osaka University in…
Immune cells that stop our body from attacking itself land a Nobel
The body’s immune system recruits certain cells to fight infections and help heal wounds. Afterwards, another group of cells will tell those recruits it’s time to stand down. That second group acts as peacemakers, getting an active immune system to calm down. Three scientists who did pivotal work to understand these peacemakers will take home this year’s 2025 Nobel Prize in physiology or medicine. Explainer: The Nobel Prize The Nobel Assembly in…
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