Transcriptomic Organization of the Human Brain in Post-Traumatic Stress Disorder

Transcriptomic organization of the human brain in post-traumatic stress disorder

Despite extensive study of the neurobiological correlates of post-traumatic stress disorder (PTSD), little is known about its molecular determinants. Here, differential gene expression and network analyses of four prefrontal cortex subregions from postmortem tissue of people with PTSD demonstrate extensive remodeling of the transcriptomic landscape. A highly connected downregulated set of interneuron transcripts is present in the most significan…

The Many Faces of PTSD: Signs of Post-Traumatic Stress Disorder

You survive—like a phoenix rising from the ashes—but the person you were before is gone. Trying to fit back into your old life now feels impossible. Some things change you forever. That’s one of the harder truths about post-traumatic stress disorder, or PTSD. As much as you may wish for life to feel normal again, or to return to old routines and joys, there is an injury to the soul that refuses to be ignored. It draws a line between who you are …