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Flu Season in the US Is Heating up, Driven by New Subclade K Variant

Subclade K's genetic changes reduce antibody recognition and increase spread; Southern Hemisphere data shows vaccination cuts hospitalization risk by nearly 50%, CDC says.

  • This year, subclade K is driving a rapidly intensifying U.S. flu season as cases rise in doctor visits, and Richard Martinello warned it will be more severe than typical during the holiday period.
  • Because the vaccine was selected almost a year earlier, the current vaccine edition mismatches the circulating strain, while genetic changes in the virus reduce antibody recognition and raise transmissibility, as seen in the Southern Hemisphere winter.
  • Vaccination coverage in the U.S. remains low among children and seniors, with just 36% of U.S. children and 13% of adults over 65 vaccinated, despite CDC analysis showing Southern Hemisphere vaccine recipients were just under 50% less likely to face hospitalization.
  • Experts say getting vaccinated is the first step to stem severity, while preventive actions like staying home and masking reduce spread; early clinical consultation is vital since antivirals remain effective.
  • Record Southern Hemisphere surges last year in Australia and Brazil signal broader risk, while global travel and holiday gatherings will magnify spread and vaccine hesitancy combined with a vaccine mismatch could worsen outcomes.
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15 Articles

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Lean Left

Flu season in the US is heating up, driven by new subclade K variant

The latest data on respiratory illness in the United States shows that shoppers and merry-makers are spreading more than just holiday cheer: They’re also passing around germs. In many cases, it’s a new virus variant that’s been causing early and busy flu seasons in Asia, Australia and Europe.

·Atlanta, United States
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The percentage of vaccinated people exceeds that of the previous two years

The new subvariate A(H3N2) subclade K expands rapidly and puts health systems in the UK, Spain and the United States under stress in the middle of the respiratory virus season.

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negocios.com broke the news in on Saturday, December 13, 2025.
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