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Brain-Wide Activity Map Reveals Decision-Making at Cellular Resolution in Mice

Researchers mapped activity of over 650,000 neurons in mice across 279 brain areas, revealing decision-making signals distributed across cortical and subcortical regions, challenging prior localization theories.

Summary by Medical Xpress
The first complete activity map of the brain has been unveiled by a large international collaboration of neuroscientists. The International Brain Laboratory (IBL) researchers published their findings in two papers in Nature, revealing insights into how decision-making unfolds across the entire brain in mice at the resolution of single cells.

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When making a decision each area of the brain lights up as a Christmas tree. To challenge the traditional belief that information processing is localized in specific brain regions was the International Brain Laboratory (IBL), a global collaboration of researchers from different universities in the United States and Europe, launched in 2017. Scientists first revealed a complete map of the brain activity of mice. The results, published in two arti…

·Rome, Italy
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Measuring with unprecedented precision of mouse brain activity while making decisions challenges traditional hierarchical vision and reveals how previous expectations shape our choices

·Spain
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For the first time the first complete map of brain activity has been obtained. The work published in the journal ' Nature ' reveals key information about the mechanisms involved in decision-making throughout the brain of mice. This map of brain activity challenges the traditional hierarchical view of information processing in the brain and demonstrates that decision-making is distributed among many regions in a highly coordinated manner. Accordi…

·Spain
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For decades, most neuroscience studies have focused on small groups of cells in isolated regions of the brain. “But this method had its flaws,” says Dr. Ilana Witten, professor of neuroscience at Princeton University and researcher at Howard Hughes Medical Institute. “The brain constantly makes decisions in everyday life, and we have realized that there are many brain regions, and not just one or two, that contribute to it.”

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Medical Xpress broke the news in on Wednesday, September 3, 2025.
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