A well-known example of the disappearing polymorph is the HIV/Aids drug ritonavir, developed by Abbott Laboratories, which gained approval in 1996. Two years later a more stable, less soluble crystalline form (form II) began appearing in manufactured batches, replacing the original form I and rendering the capsules ineffective.More sources:
Derek Lowe (one of many previous) discusses the"unintentional crystalline seed" hypothesis: that a tiny am…
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