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Structures of the mumps virus polymerase complex via cryo-electron microscopy

Summary by Nature
The viral polymerase complex, comprising the large protein (L) and phosphoprotein (P), is crucial for both genome replication and transcription in non-segmented negative-strand RNA viruses (nsNSVs), while structures corresponding to these activities remain obscure. Here, we resolved two L–P complex conformations from the mumps virus (MuV), a typical member of nsNSVs, via cryogenic-electron microscopy. One conformation presents all five domains o…

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Structures of the mumps virus polymerase complex via cryo-electron microscopy

The viral polymerase complex, comprising the large protein (L) and phosphoprotein (P), is crucial for both genome replication and transcription in non-segmented negative-strand RNA viruses (nsNSVs), while structures corresponding to these activities remain obscure. Here, we resolved two L–P complex conformations from the mumps virus (MuV), a typical member of nsNSVs, via cryogenic-electron microscopy. One conformation presents all five domains o…

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The Coming Mumps Dystopia: Weekend Open Thread

Better tighten your belts and prepare for the worse, says Antoniono! The post The Coming Mumps Dystopia: Weekend Open Thread first appeared on Orange Juice Blog.

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orangejuiceblog.com broke the news in on Monday, March 10, 2025.
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