Tennessee vs. Iowa State prediction, odds, spread, time: 2026 NCAA Tournament picks from proven model

Iowa State Basketball vs Tennessee Sweet 16 Bold Predictions

Here are some bold predictions for the matchup between the Iowa State Cyclones and Tennessee Volunteers in the Sweet 16 of the 2026 NCAA Tournament.

No. 2 Iowa State vs. No. 6 Tennessee: Kalshi markets, prediction and picks for Friday’s Sweet 16 showdown

Four teams have advanced onto the Elite Eight while there are still four games left to be played for the Sweet 16. The round will be finalized tonight when the No. 2-seed Iowa State Cyclones take on the No. 6-seed Tennessee Volunteers with tip-off scheduled for 10:15 p.m. EST. The winer will face the Alabama-Michigan winner for a chance to win the Midwest Region.

Tennessee vs. Iowa State prediction, odds, spread, time: 2026 NCAA Tournament picks from proven model

SportsLine's model simulated Iowa State Cyclones vs. Tennessee Volunteers and revealed its college basketball picks for this NCAA Tournament 2026 Sweet 16 matchup on Friday

Let's Cash Some Plays To Close Out The Sweet Sixteen

Tennessee vs. Iowa State, 10:10 ETThis is the final game to determine the last spot on the Elite Eight. After this one, it means we are down to just seven games remaining in the NCAA Tournament, and we will have a new champion. While there have been a lot of talking heads saying this wasn't an exciting tournament, there were seven games decided by three points or fewer. There were at least another couple of games that were decided by four points…

Tennessee vs Iowa State Predictions, Picks, Odds

Read our Tennessee vs Iowa State predictions, picks and odds for their Sweet 16 game on Friday, March 27.

Tennessee vs. Iowa State predictions: ISU -3.5, Lipsey assists

The post Tennessee vs. Iowa State Predictions: Cyclones to Cover, Lipsey Assists appeared first on SportsHandle. Two of the most physically imposing, defense-oriented programs in the country will meet in this Sweet 16 matchup. The only unanswered question is whether forward Joshua Jefferson will be able to help his Cyclones after an ankle injury. In this Tennessee vs. Iowa State predictions preview, the focus is on turnover creation, structured …