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T-Cell Exhaustion Driven by Lipid Checkpoint PTGIR in Tumors
Summary by Inside Precision Medicine
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T-Cell Exhaustion Driven by Lipid Checkpoint PTGIR in Tumors
Researchers at the Van Andel Institute and their collaborators say they have identified a previously unrecognized immune checkpoint that promotes T cell exhaustion through a lipid-mediated signaling pathway. The findings, published in Nature Immunology, show that PTGIR, a receptor for the lipid prostacyclin, functions as an immune checkpoint in CD8+ T cells, thus broadening the landscape of potential targets for immune checkpoint inhibitor (ICI)…
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