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Universal mRNA Vaccine Eradicates Tumors in Mice nd Advances Toward Human Trials
ALACHUA COUNTY, FLORIDA, JUL 18 – The vaccine increased tumor-fighting immune responses in mice, eliminating some tumors and enhancing effects of checkpoint inhibitors, advancing toward human trials, researchers said.
- Last year, University of Florida researchers developed an experimental mRNA cancer vaccine, uniquely stimulating immune responses as if fighting a virus.
- Prior work in mRNA technology led to the development of an experimental vaccine that stimulates immune responses, explaining the scientific rationale.
- Animal studies revealed that in mouse models, the vaccine triggered a strong anticancer response, with some tumors completely eradicated, even without targeting specific cancer types.
- Sayour noted the vaccine's broad potential as an alternative to surgery, radiation, and chemotherapy, highlighting its implications for treatment-resistant tumors.
- Next steps include refining the vaccine formulations and moving toward human clinical trials, bringing us closer to a universal cancer vaccine with broad therapeutic potential.
39 Articles
39 Articles
New UF study shows potential for universal cancer vaccine
On July 18th, a University of Florida research team published a study discussing their recent developments in a universal cancer vaccine. They have been working towards a goal to stimulate the immune system to fight against cancer. They created a generalized mRNA vaccine and paired it with common anticancer drugs to prompt a strong immune system response. They observed that using the vaccine to activate immune responses could prompt T cells to …
A tiny chemistry hack just made mRNA vaccines safer, stronger, and smarter
What if mRNA vaccines could be made more powerful and less irritating? Scientists at the University of Pennsylvania have found a way to do just that—by tweaking a key molecule in the vaccine’s delivery system. Using a century-old chemical trick called the Mannich reaction, they added anti-inflammatory phenol groups to the lipids that carry mRNA into cells. The result? A new class of lipids that reduce side effects, boost gene-editing success, fi…
der Standard AT
der Standard DEA new vaccine could pave the way for universal cancer vaccinations that "incite" the immune system against tumours in affected patients
An experimental ARN messageer-based vaccine (ARNm) has broadened the effects of immunotherapy tumors in a study conducted on rats, bringing researchers closer to their goal: developing a universal vaccine to...
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