Study unveils powerful strategy to rejuvenate effectiveness of CAR T cell therapy against glioblastoma

A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for patients with recently diagnosed glioblastoma

Despite great interest, there is limited clinical evidence to support the use of a ketogenic diet (KD) for cancer patients. We conducted a single-arm phase 1 trial of a KD among patients with recently diagnosed glioblastoma (GBM) receiving standard-of-care (SOC) treatment. Adults with GBM within 3 months of diagnosis followed a supervised 16-week intervention of a 3:1 KD (Fat(g): Carbohydrate + Protein(g)) plus SOC chemoradiation. The primary ou…

Study unveils powerful strategy to rejuvenate effectiveness of CAR T cell therapy against glioblastoma

A team of researchers from the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan), led by Nadia Coltella and Luigi Naldini, has unveiled a powerful strategy to rejuvenate the effectiveness of chimeric antigen receptor (CAR) T cell therapy against glioblastoma, one of the most lethal and treatment-resistant brain tumors.

Glioblastoma CAR T-Cell Therapy Improved by New Strategy

A research team headed by scientists at the San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET, Milan) has identified what they say is a powerful strategy to rejuvenate the effectiveness of chimeric antigen receptor (CAR) T-cell therapy against glioblastoma (GBM), one of the most lethal and treatment-resistant brain tumors. Led by Nadia Coltella, PhD, and Luigi Naldini, MD, PhD, the preclinical study findings highlight how gene therapy t…