Single-Cell Analysis Illuminates Myeloma Immune Landscape

Single-cell analysis illuminates myeloma immune landscape

Scientists at the Icahn School of Medicine at Mount Sinai, in partnership with the Multiple Myeloma Research Foundation (MMRF) and in collaboration with leading institutions across the country, have helped generate the largest single-cell immune cell atlas of the bone marrow in patients with multiple myeloma, a blood cancer that, while treatable, remains incurable.

Inflammatory immune cells predict survival and relapse in multiple myeloma

A new study maps the immune cell landscape of bone marrow in patients with multiple myeloma, a rare cancer that develops in the plasma cells of the bone marrow and has no cure. This large immune cell atlas, which includes robust patient outcome data, provides unparalleled new insights into how the immune system interacts with cancerous plasma cells and can be used to determine how aggressive a patient's multiple myeloma is likely to be.

Largest Immune Cell Atlas of Multiple Myeloma Predicts Recurrence Risk

Scientists across six leading U.S. institutions have created the largest single-cell immune cell atlas to date, using data from over a million bone marrow cells sourced from multiple myeloma patients. A study published today in Nature Cancer shows that evaluating the immune system’s response to myeloma could complement traditional genetic testing to improve predictions of which patients are at a high risk of relapse after treatment.  “Currently,…

Study Maps Immune Cell Landscape in Bone Marrow to Predict Survival and Relapse in Multiple Myeloma Patients

A recent study has mapped the immune cell landscape of […] The post Study Maps Immune Cell Landscape in Bone Marrow to Predict Survival and Relapse in Multiple Myeloma Patients first appeared on GeneOnline News. The post Study Maps Immune Cell Landscape in Bone Marrow to Predict Survival and Relapse in Multiple Myeloma Patients appeared first on GeneOnline News.

Bone Marrow Immune Cell Map Boosts Survival, Relapse Prediction in Multiple Myeloma

A map of the immune cell landscape found in the bone marrow of patients with multiple myeloma could shed light on how the immune system interacts with cancerous plasma cells. It could also help scientists determine how aggressive a patient’s cancer is likely to be, as well as drive the development of more effective immune-based therapies.   The map is the subject of a new Nature Cancer paper titled “A single-cell atlas characterizes dysregulatio…

Inflammatory Immune Cells Predict Survival, Relapse in Multiple Myeloma

Researchers at WashU Medicine and their collaborators have created an immune cell atlas of multiple myeloma, a cancer of the bone marrow. The new resource could improve prognosis and guide development of new immunotherapies.