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Study Finds Surprising Link Between Gut and Brain Rhythms

UC San Diego researchers explain how gut muscle rhythms synchronize brain blood vessel pulses, a discovery that may aid treatments for brain and digestive disorders.

  • On SUNDAY, Nov. 2, 2025, researchers at the University of California San Diego led by Massimo Vergassola and David Kleinfeld reported the gut's rhythmic muscle movements could help explain synchronized brain blood vessel activity.
  • Facing a long-standing puzzle about vascular synchronization, the UC San Diego team turned to the digestive system because intestines contract as coupled oscillators forming a staircase pattern.
  • Using mathematical models, the team demonstrated nearby oscillators in gut and brain can lock rhythms when frequencies align, revealing step-like transitions and explaining synchronized arteriole pulses during neuronal stimulation.
  • The researchers say the findings could eventually help develop new treatments for digestive and brain-related conditions, and David Kleinfeld, professor of physics and neurobiology at UC San Diego, called this a critical advance given the brain's complexity.
  • Published recently in Physical Review Letters, the study suggests the staircase pattern could help explain how brain blood vessels synchronize their rhythms.
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Study Finds Surprising Link Between Gut and Brain Rhythms

SUNDAY, Nov. 2, 2025 (HealthDay News) — The human body is packed with natural rhythms, from your sleep-wake cycle to the steady pulsing of blood through the brain to heart rate and pulse.

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U.S. News broke the news in New York, United States on Sunday, November 2, 2025.
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