Study finds new weak spot linked to DNA repair in aggressive, drug-resistant cancers

Study finds new weak spot linked to DNA repair in aggressive, drug-resistant cancers

A new way for hard-to-treat cancer cells to protect themselves from being killed by anticancer drugs has been found. The novel method involves tumors hijacking specific defenses for repairing damaged DNA, which are easier to block than previously known mechanisms.

DNA Damage Response Pathways Inform New Cancer Immunotherapy Strategies

The DNA damage response (DDR) and the immune system may look like separate defense networks, but new research underscores how tightly they can cooperate to shape outcomes in cancer immunotherapy. DDR normally preserves genomic stability, while immune surveillance protects the host by recognizing abnormal cells. In many tumors, however, DDR pathways are compromised, either by […]

The DNA Damage Response and Cancer Immunotherapy

The authors examine the molecular mechanisms by which DNA damage response (DDR) defects potentiate immunotherapy, including recent advances in DDR-targeted combination strategies. [Nature Reviews Cancer] Abstract