Study establishes a causal link between mitochondrial dysfunction and neurodegenerative diseases

Scientists reversed memory loss by powering the brain’s tiny engines

Scientists have discovered a direct cause-and-effect link between faulty mitochondria and the memory loss seen in neurodegenerative diseases. By creating a novel tool to boost mitochondrial activity in mouse models, researchers restored memory performance, suggesting mitochondria could be a powerful new target for treatments. The findings not only shed light on the early drivers of brain cell degeneration but also open possibilities for slowing …

Study establishes a causal link between mitochondrial dysfunction and neurodegenerative diseases

Mitochondria, the tiny organelles without which our bodies would be deprived of energy, are gradually revealing their mysteries.

Neurodegenerative diseases: Research establishes causal link between mitochondrial dysfunction and cognitive symptoms

Mitochondria, the tiny organelles without which our bodies would be deprived of energy, are gradually revealing their mysteries. In a study published in Nature Neuroscience, researchers from Inserm and the University of Bordeaux at the NeuroCentre Magendie, in collaboration with researchers from the Université de Moncton in Canada, have for the first time succeeded in establishing a causal link between mitochondrial dysfunction and the cognitive…

First proof brain’s powerhouses drive – and can reverse – dementia symptoms

Just a few days after scientists announced we're at a pivotal tipping point in Alzheimer's disease research, a team has made a huge breakthrough, proving for the first time how mitochondrial dysfunction fuels neurodegenerative symptoms. Through this, they created a precision tool that restored memory function in several dementia models.Continue ReadingCategory: Alzheimer's & Dementia, Brain Health, Body & MindTags: Alzheimer's disease, Brain, Co…

Mitochondria-Targeted Receptor Counters Neurodegeneration in Mice

A team from Inserm (Institut national de la santé et de la recherche médicale) and the Université de Bordeaux, working with collaborators at the Université de Moncton in Canada, has developed a molecular tool that could change how scientists approach neurodegenerative disease treatment. Their study, “Potentiation of mitochondrial activity by mitoDREADD-Gs reverses pharmacological and neurodegenerative impairment of cognition,” published in Natur…