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Study: Brain Training Reverses 10 Years of Cognitive Aging in World First

A 10-week BrainHQ training restored cholinergic function to levels typical of someone 10 years younger in 92 adults aged 65+, a first in demonstrating neurochemical aging reversal.

  • McGill University-led clinical trial showed the BrainHQ app enhanced cholinergic function and improved learning and memory networks in humans after 10 weeks of use.
  • Researchers note the cholinergic system declines with age and collapses in Alzheimer's disease, reducing acetylcholine that supports attention, memory and decision-making, prompting non-pharmacological options.
  • 92 adults aged 65 and older trained 30 minutes daily on tablets for 10 weeks, and PET scans using a rare tracer at The Neuro showed only BrainHQ produced a 2.3 percent binding increase.
  • Senior author Dr Etienne de Villers-Sidani said the training restored cholinergic health to levels typically seen in someone 10 years younger, and researchers say BrainHQ offers a lower-risk alternative to medication.
  • This world-first study shows computerized training can upregulate acetylcholine in humans, and BrainHQ features in more than 300 published studies.
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A clinical trial in Montreal highlights the changes that occur as a result of this training.

·Montreal, Canada
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Medical Xpress broke the news in on Tuesday, October 14, 2025.
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