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Study: Amphetamines Double Stroke Risk

A meta-analysis of over 100 million people found amphetamines nearly triple stroke risk in under-55s, with cocaine and cannabis also increasing risk significantly.

  • Published March 9 in the International Journal of Stroke, researchers reported recreational drug use was linked to a higher stroke risk, especially among younger adults.
  • To probe causation, researchers combined Mendelian randomisation with a meta-analysis pooling cohort data of more than 100 million people, addressing uncertainty from prior observational studies.
  • Amphetamines and cocaine were associated with large percentage increases in stroke risk, with cocaine up 96%, amphetamines 122%, cannabis 37%, and disordered cocaine use linked to brain haemorrhage and cardioembolic stroke.
  • With stroke already a leading global health burden, researchers urged action as stroke affects around 100,000 people annually in the UK and drugs place huge stress on the cardiovascular system, the University of Cambridge team said.
  • Genetic analyses point to causality for some drugs, but Mendelian randomisation could not assess amphetamines due to lack of large datasets, while 2024 ONS drug-use figures show around 2.9 million adults reported use.
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The Independent broke the news in London, United Kingdom on Sunday, March 8, 2026.
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