Stress-related brain signals drive risk of cardiovascular disease in people with depression and anxiety

Stress-related brain signals drive risk of cardiovascular disease in people with depression and anxiety

Patients with depression are at higher risk of cardiovascular disease, and a new study suggests that stress may help explain why. Research from Mass General Brigham suggests that this increased risk is driven by stress-related brain activity, nervous system dysregulation, and chronic inflammation. They also found that patients with both depression and anxiety were at even higher risk of cardiovascular disease than those diagnosed with just one c…

Depression Quietly Damages the Heart Through Stress Circuits

Depression and anxiety may heighten cardiovascular disease risk through chronic stress pathways in the brain and body. In a large analysis of more than 85,000 adults, those with depression or anxiety — especially both — were significantly more likely to experience heart attack, stroke or heart failure.

Why cardiovascular disease and depression often develop together

Major project identifies shared mechanisms and biological pathways that affect patient outcomes