Stop the nonsense: genome editing creates potentially therapeutic transfer RNAs

Stop the nonsense: genome editing creates potentially therapeutic transfer RNAs

Genome editing has been used to generate a type of transfer RNA that overcomes the harmful effects of ‘nonsense’ gene variants — a possible remedy for a range of diseases. Genome editing has been used to generate a type of transfer RNA that overcomes the harmful effects of ‘nonsense’ gene variants — a possible remedy for a range of diseases.

Single Prime Editing Platform Shows Potential vs. Multiple Diseases

A new paper from the laboratory of David Liu, PhD, at the Broad Institute describes a genome-editing strategy that could result in a one-time treatment for multiple unrelated genetic diseases. The new technique dubbed prime editing-mediated readthrough of premature termination codons or PERT is detailed in Nature in a new paper titled “Prime editing-installed suppressor tRNAs for disease-agnostic genome editing.” The work is spearheaded by co-fi…