US EditionScientists Discover How Stem Cells Navigate and Repair Brain Damage After Stroke
Researchers identified a transcriptional navigation code enabling human stem-cell neurons to survive, grow, and restore neural circuits in stroke cavities in mice, aiding regenerative medicine.
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5 Articles
Stem cell therapy for stroke shows how cells find their way in the brain
Some parts of our bodies bounce back from injury in fairly short order. The outer protective layer of the eye—called the cornea—can heal from minor scratches within a single day. The brain is not one of these fast-healing tissues or organs. Adult brain cells are stable and last for a lifetime barring trauma or disease, whereas some cells lining our guts last only five days and must be continually replaced.
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elcorreogallego.esScientists tested human stem cell-derived therapy for neuronal regeneration. When transplanted to mice, the cells matured, integrated into existing circuits and restored their function. By tracking cells and sequencing their patterns of genetic expression, researchers also revealed how transplanted cells find where they should go and form connections to the nervous system.
Stem Cell-Derived Neurons Navigate to Form Connections in the Injured Brain
Some parts of the body can recover from injury fairly rapidly. The cornea, for example, can heal from minor scratches within a single day. The human brain, however, is not one of these fast-healing tissues or organs. Adult brain cells are stable and last for a lifetime— barring trauma or disease—while some cells lining the gut last only five days and must be continually replaced. Scientists would like to use stem cell therapy to boost the brain’…
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