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Stanford AI Predicts 130 Diseases from One Night of Sleep

SleepFM, trained on 585,000 hours of data from 35,000 patients, predicts risk for 130 diseases including cancers and neurological disorders with strong accuracy.

  • On January 6, 2026, Stanford Medicine researchers published a Nature Medicine paper introducing SleepFM, an AI that estimates risk for 130 diseases from one night of sleep.
  • Polysomnography captures brain, heart, respiratory, eye and muscle signals overnight, providing detailed physiological data that much went unused until recent AI advances enabled full analysis.
  • Trained on nearly 600,000 hours of polysomnography from about 65,000 participants, SleepFM used five-second segments and leave-one-out contrastive learning to harmonize data modalities.
  • Strong performance for major condition groups indicates SleepFM spots subtle mismatches among brain, heart and breathing signals, achieving a C-index higher than 0.8 for cancers, pregnancy complications, circulatory diseases and mental disorders.
  • Using decades of clinic records, the researchers linked Stanford Sleep Medicine Center records with electronic health records with up to 25 years follow‑up, but no single signal suffices so researchers are working on interpretation and wearable integration.
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Stanford researchers develop SleepFM, an AI that analyzes sleep data to predict risks of serious diseases such as dementia and heart attack.

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sleepworldmagazine.com broke the news in on Friday, November 22, 2024.
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