Spermidine Halts Liver Fibrosis by Cell Signal Remodeling

Spermidine Suppresses Liver Fibrosis by Remodeling the Communication Signal between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells

Analysis of NHANES data revealed an inverse association between dietary spermidine (SPD) intake and fibrosis risk. Consistently, in vivo and in vitro models demonstrated that SPD significantly ameliorated liver sinusoidal endothelial cells dysfunction and attenuated fibrosis progression. [Cell Death Discovery] AbstractGraphical Abstract

Spermidine Halts Liver Fibrosis by Cell Signal Remodeling

In a groundbreaking advance for the field of hepatic disease and regenerative medicine, recent research has unveiled a promising role for spermidine in combating liver fibrosis through a sophisticated mechanism involving the cellular crosstalk between liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs). The study, conducted by Zeng, Liu, Jin, and colleagues, published in Cell Death Discovery in 2026, explores the intrica…