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Test Predicts Dementia Risk in Women 25 Years Before Memory Loss
Higher blood plasma levels of phosphorylated tau 217 predict dementia risk in women up to 25 years before symptoms, based on data from over 2,700 participants, researchers said.
- On Tuesday, researchers at the University of California, San Diego reported higher plasma p-tau217 in older women predicted dementia risk up to 25 years ahead in JAMA Network Open.
- Using baseline samples from the Women’s Health Initiative Memory Study, researchers measured p-tau217 in blood from over 2,500 dementia-free women aged 65 to 79 in the late 1990s and followed them for up to 25 years.
- Subgroup analysis found stronger associations in older and genetically at-risk women, as dementia risk rose with higher p-tau217 levels, especially in participants over 70, APOE ε4 genetic risk carriers, and women randomized to oestrogen plus progestin.
- Authors warned that despite promise, study authors said the lead time could enable earlier prevention strategies and targeted monitoring, but cautioned blood biomarkers are not recommended for people without symptoms and called for more studies on preventive trials and routine clinical care.
- Researchers say further validation in men and diverse groups is required, as two FDA-cleared blood tests using p-tau217 exist but wider clinical use remains premature; planned work will explore hormone therapy, genetics and age-related conditions.
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32 Articles
32 Articles
ABC FOX Montana+23 Reposted by 23 other sources
Blood test can detect dementia in women 25 years before symptoms begin
Scientists believe their findings open the way to earlier prevention strategies and more targeted monitoring.
·Missoula, United States
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Total News Sources32
Leaning Left4Leaning Right6Center7Last UpdatedBias Distribution41% Center
Bias Distribution
- 41% of the sources are Center
41% Center
L 24%
C 41%
R 35%
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