Semaglutide extends lifespan and slows physiological aging in healthy mice
The drug improved muscle and memory measures and added nearly 100 days to median lifespan in treated animals, researchers said.
- An NIH-funded study published in Nature shows the GLP-1 drug semaglutide extended lifespan in healthy older mice by tempering detrimental effects of aging.
- Researchers at the University of California, Berkeley, led by Danica Chen, compared semaglutide to a 24% calorie-restricted diet over five months in 20-month-old female mice.
- Treated C57BL mice showed improved muscle and cognitive function, with median lifespan nearly 100 days longer than untreated groups. The GLP-1R agonist reduced hallmarks of aging including inflammation.
- "Most chronic diseases are deeply rooted in the aging process," said Rafael de Cabo, Ph.D., a senior investigator at the NIH's National Institute on Aging. He noted clinical benefits are expected if GLP-1 agonists slow aging.
- Future clinical investigations, such as the recent post-hoc analysis of the SLIM LIVER trial, are necessary to determine human efficacy. Researchers caution these findings do not imply similar results could be achieved immediately in humans.
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Semaglutide shows results against aging Freepik A medicine used in the treatment of obesity and diabetes can have an effect that goes beyond weight control: delay aging. This is what suggests a study published in the scientific journal Nature this week. Researchers at the University of California in Berkeley treated elderly mice with Semaglutide, a substance used in weight loss medicines, and observed that they lived, on average, 12% more than t…
Subjecting to a strict caloric restriction, either by reducing food intake or by subjecting to intermittent fasting, is one of the keys that often handle those who investigate aging to delay the biological clock and ultimately extend life expectancy. However, transferring this Spartan rigor to humans is not easy, because for many patients living in hunger is not an attractive recipe, much less in the long term. An alternative could be in the sam…
Researchers think that the anti-ageing effect also occurs in people, but warn that there is a lack of studies to prove it.
Wigobi Ingredient Extends Lifespan of Female Mice by 12%: International Joint Research Team Including UC Berkeley Alleviates Cellular Aging and Increases Nerve Cell Production. Animal experiment results indicate that semaglutide, the active ingredient in the obesity treatment Wigobi and the diabetes treatment Ozempic, goes beyond simple weight loss effects to slow aging and extend lifespan, according to international academic research.
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