Scientists Unveil Lipid Nanoparticle Surface Structures Poised to Enhance

Next Steps in Driving Forward the Field of Nanomedicine: A Catch-up with the Leslie Lab - Science in Vancouver

The lab of Dr. Sabrina Leslie (MSL, Physics and Astronomy; SBME affiliate member) brings together researchers and approaches from physics and biology to drive forward the field of nanomedicine. Their work involves the use of their high-resolution Convex Lens-induced Confinement (CLiC) imaging technology to look closely at lipid nanoparticles (LNPs), which can act as delivery vehicles in therapeutics like the COVID-19 mRNA vaccines. By watching t…

Scientists Unveil Lipid Nanoparticle Surface Structures Poised to Enhance

In a groundbreaking advancement poised to revolutionize the field of drug delivery and vaccine development, scientists at the University of Nottingham’s School of Pharmacy have unveiled a pioneering technique for analyzing the intricate architecture of lipid nanoparticles (LNPs). These microscopic carriers are essential vectors in the delivery of RNA-based therapeutics, including the widely recognized COVID-19 vaccines developed by Moderna and P…

Cryo-MS Reveals Lipid Nanoparticles’ Surface Secrets

Using cryogenic mass spectrometry, scientists from the University of Nottingham’s School of Pharmacy and their collaborators elsewhere developed an approach for depth profiling frozen lipid nanoparticles (LNPs) to reveal the layers and orientation of the constituent molecules. Their research provides insights into the relative positions of each component within lipid nanoparticles that could help clarify LNP behavior and contribute to the design…