Transplantation of Tissues Grown From Stem Cells Opens a Way to Treat Lifelong Hormonal Disorders
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In regenerative medicine, the cultivation of a pituitary organoid represents a significant advance to restore the endocrine system. Specialists managed to implant this cell tissue in an animal model and recorded the sustained hormonal production over weeks. How was the experiment conducted with the pituitary organoid? Researchers from the University of Nagoya used...
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A team of researchers led by the University of Nagoya in Japan has achieved for the first time that human pituitary tissue grown from stem cells survives and works after being transplanted to a primate. The experiment, carried out in a macaque monkey that had surgically removed the pituitary gland, managed to recover an essential hormonal signal and raise cortisol levels.
The Japanese study, published in Stem Cell Research & Therapy, showed that the tissue generated survived and worked well in a macaque monkey without pituitary gland, although immune rejection remains a challenge for its application in humans.
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