US EditionHow Cholera Virulence Is Activated: A Long-Sought Structural Explanation
The study reveals cholera virulence activation by stabilizing RNA polymerase on DNA, identifying a key amino acid and suggesting antibiotic repurposing options amid millions of annual cases.
3 Articles
3 Articles
How cholera virulence is activated: A long-sought structural explanation
Cholera remains a major global public health challenge, with an estimated 1.3 to 4 million cases and tens of thousands of deaths reported worldwide each year. Caused by the bacterium Vibrio cholerae, the disease spreads primarily through contaminated water and food and continues to disproportionately affect regions with limited access to safe sanitation.
Published in Science Advances, the work has mapped through electronic cryomicroscopy the infection process with unprecedented detail and opens up new future and accessible therapeutic pathways. Although molecular switches that regulate the spread of cholera in the intestine were already known, the 3D map of how they interact with the transcription engine of the bacterial cell, polymerase RNA, was unknown. Now, this new study reveals the molecula…
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