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Columbia Scientists Find Gene that Drives Prostate Cancer
The study found that blocking SIRT1 in mice reduced neuroendocrine prostate cancer growth and reversed the cancer state in cells.
- Researchers at Columbia University Irving Medical Center identified Sirtuin1 as a driver of neuroendocrine prostate cancer in a study published in the Journal of Experimental Medicine.
- While androgen deprivation therapy is the standard treatment for prostate cancer, it eventually fails, causing tumors to transition into the aggressive, ADT-insensitive variant known as NEPC.
- Columbia University Professor Cory Abate-Shen's team screened mice for recurring mutations, identifying 75 candidate genes before determining that silencing SIRT1 profoundly reduced tumor growth.
- The researchers found that Selisistat, an FDA-approved SIRT1-inhibitor developed for Huntington's disease, significantly reversed the NEPC phenotype in mice, establishing a potential path for human treatments.
- Abate-Shen, who co-led the study with fellow professor Andrea Califano, stated, "Elucidating the mechanisms governing this process may improve treatment by overcoming plasticity-associated drug resistance.
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Columbia scientists find gene that drives prostate cancer
The breakthrough at Columbia University lays the groundwork for future clinical studies aimed at developing new treatments.
·Chariton, United States
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Target for Aggressive Prostate Cancer Prevention Identified in Mice
Researchers at Columbia University Irving Medical Center have identified a gene that drives the development of neuroendocrine prostate cancer (NEPC), an aggressive form of the disease. Their study showed that genetic or pharmacological inhibition of Sirtuin 1 prevents the growth of NEPC tumors in mice, laying the groundwork for future clinical studies aimed at developing new treatments for NEPC in humans. Research lead Cory Abate-Shen, PhD, a pr…
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Leaning Left3Leaning Right9Center15Last UpdatedBias Distribution56% Center
Bias Distribution
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56% Center
11%
C 56%
R 33%
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