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Tobacco Plant Engineered to Produce 5 Psychedelic Compounds

The modified Nicotiana benthamiana plants produced DMT, psilocin, psilocybin, bufotenin and 5-MeO-DMT, giving researchers a possible new source for studies.

  • Researchers at the Weizmann Institute of Science engineered Nicotiana benthamiana tobacco plants to simultaneously produce five psychedelic compounds—DMT, psilocybin, psilocin, bufotenin, and 5-MeO-DMT—reported in Science Advances.
  • Traditionally, psychedelic supply relies on plants, fungi, and the Sonoran Desert toad, which face habitat loss and overexploitation. Professor Asaph Aharoni of the Weizmann Institute warned that harvesting these organisms risks depleting threatened populations.
  • Utilizing a technique called agroinfiltration, the team introduced nine genes into the plants, which then manufactured the required proteins. The introduced DNA does not integrate into the plant's genome, making the modification non-heritable.
  • Biochemist Paula Berman noted the approach could provide a reliable, eco-friendly supply for mental health research. "We realized that we had a big opportunity to reconstruct all these pathways in one plant," she said.
  • While bioengineer Andrew Jones of Miami University suggests microbes might ultimately prove more practical for industrial production, researchers are currently exploring how to process the plants for extraction and scale the system.
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Science broke the news in on Wednesday, April 1, 2026.
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